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Tail flick latencies before and after microinjections into the ventrolateral PAG of vehicle, capsaicin (3 and 6 nmol/rat) alone or in combination with I-RTX (0.5 nmol/rat) (A), and vehicle or I-RTX (0.5 and 1 nmol/rat) (B). Each point represents the mean ± SEM of 8–10 observations. * indicates significant differences versus vehicle; ° indicates significant differences versus capsaicin (6 nmol/rat). p values <0.05 were considered statistically significant.
