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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Immunol Rev. 2015 Sep;267(1):16–29. doi: 10.1111/imr.12322

Fig. 1. Proposed model for the activation of CD1a-autoreactive T cells.

Fig. 1

Small apolar lipids without headgroups (left panel) nest in the CD1a groove and allow interactions between the T-cell receptor (TCR) and CD1a. Lipids with large polar headgroups (right panel), which protrude from the CD1a groove, inhibit interactions between TCR and CD1a.