Collagen visualization after 6 days (A–C) and 20 days (D–F) culture Optical micrographs displaying extracellular matrix collagen as a result of MC3T3-E1 subclone 4 exposure to (A), (D) control media + AA + βGP treatment, 6P53-b GCM treatment, (B), (E) and 45S5 GCM treatment, (C), (F) over a 6-day and 20-day period, respectively. White and black arrows indicate elongated collagen fibers aligned in orthogonally oriented layers.