Fig. 6.

A, activation curves and kinetics of deactivation for Kv11.1-HA-WT (n = 8; open square) or for Kv11.1-HA-R887H (n = 8; orange circle). I/Imax at −120 mV is plotted versus the preceding depolarization. Data are means ± S.E. B, amplitude histograms of the basal Kv11.1-HA-WT (n = 8) or Kv11.1-HA-R887H (n = 8) channels. C, time course of the Kv11.1-HA-WT inactivation response in cells treated for 2 h with PMA or Kv11.1-HA-S890A. D, time course of recovery from inactivation of Kv11.1-HA-R887H compared with that for the WT channel. Data are means ± S.E. *, P < 0.05.