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. 2019 Aug;29(8):1352–1362. doi: 10.1101/gr.243477.118

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© 2019 Meleshko et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 6. — Effect of bubble restoration on the reconstruction of the CALC BGC. Schematic representation of repeat collapsing and consensus deterioration in the case of the CALC BGC assembly. While SPAdes outputs a single (and incorrect) consensus sequence of all three collapsed A-domains, these three sequences are not identical. In contrast, biosyntheticSPAdes utilized restored domains and reconstructed their distinct sequences with 100% accuracy (as compared to 99.6% accuracy for SPAdes). Numbers near dashed vertical lines represent the column numbers in the multiple alignment of three A-domain.