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. 2019 Aug;29(8):1298–1309. doi: 10.1101/gr.240861.118

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© 2019 Patterson et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genome Research, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 6. — Modeled comparison of RNAP3 TSS and Ty3 integration TSD. (A) RNAP3 complex is recruited by the TFIIIB complex containing Brf1, Spt15, and Bdp1 that binds ∼20–40 bases upstream of the tDNA. RNAP3 subunit Rpc34 is positioned near the active site of the TSS and transcription bubble (Wu et al. 2012). (B) Suggested model of Ty3 integration into target DNA at or near the TSS. Ty3 integration complex is recruited to target sites via interactions with Brf1. Ty3 cDNA integration may require bending of the host DNA into the integrase complex active site to facilitate strand transfer with Ty3 cDNA ends. Model suggests that flexibility of this region contributes to integration, whereas stiffness corresponding to curvature does not.