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A, Schematic representations of PrP with the regions considered for the PrP 82–146 peptide synthesis. B, Summary of the chemicophysical features of the PrP 82–146 peptides (percentage ± SE). The differences between fibrillar and amorphous aggregates were defined by EM examination. +, ++, and +++ indicate minimal, equal, and a large part of the preparation in amorphous or structured form, respectively. nd, Not detectable.
