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Amyloid and nonamyloid forms of PrP 82–146 are toxic to rat cortical neurons. Cortical cells from rat embryos (E17) were treated with PrP 82–146 peptides at the concentrations indicated, and cell viability was determined after 7 d by MTT assay. All peptides, except of PrP 82–146scr, significantly reduced viability. Data are the mean ± SEM of 20–30 replicates from three to four independent t tests. *p < 0.01 versus control group by Dunnett's test.
