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PrP 82–146wt induces nuclear fragmentation of cortical neurons. Cortical neurons from C57BL/6J × CBA/J pups were exposed to the vehicle (A), PrP 82–146wt (B), or PrP 82–146scr (C) 25 μm for 7 d. Cells were analyzed by fluorescence microscopy after staining with the DNA-binding fluorochrome bisbenzimide (Hoechst 33258). The arrows indicate nuclei with typical apoptotic features. Scale bar, 20 μm.
