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Anti-oligomeric antibody antagonized the toxicity of PrP 82–146wt. Cortical cells from rat embryos (E17) were treated with PrP 82–146 (10 μm) and anti-oligomeric antibody (ab, A11) at two concentrations: 1 and 4 μg/ml. The cell viability was determined after 7 d by MTT assay. Data are the mean ± SEM of 8–10 determinations. Ab 4 μg/ml, ANOVA (2 × 2) analysis: Fint = p < 0.01; *p < 0.05; **p < 0.01 versus control group by Tukey's test.
