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. 2007 Feb 14;27(7):1725–1737. doi: 10.1523/JNEUROSCI.4116-06.2007

Figure 8.

Figure 8.

Delayed developmental decrease of NMDA EPSCs in CaV1.3−/− mice. A, EPSCs recorded at Vh = +40 mV in synapses of wt (A1, black) and CaV1.3−/− (A2, red) mice before (dotted lines) and after (solid lines) hearing onset. A3, Same traces after normalizing their AMPA EPSC peaks to compare NMDA/AMPA EPSC ratios. B, Average values of NMDA/AMPA EPSC ratios for P14–P17 synapses were significantly larger in CaV1.3−/− mice (red). EPSC amplitudes were measured at Vh = −40 mV (EPSCAMPA) and Vh = +40 mV (EPSCNMDA). C, Scatter plot of EPSCNMDA versus age. During development, NMDA EPSC peak amplitudes decreased strongly in synapses of wt (black) but only little in those of CaV1.3−/− mice (red). EPSCNMDA was measured >10 ms after the AMPA EPSC peak when the fast EPSC component had decayed to <1% of its peak. At P14–P17, average peak amplitudes of EPSCNMDA were more than three times larger in CaV1.3−/− (4.2 ± 0.45 nA) compared with wt synapses (1.6 ± 0.21 nA). D, Decay time constants of EPSCNMDA decreased similarly during development in wt and CaV1.3−/− mice.