Figure 7.

Arrival time and BW of HFI predict 50% cutoff rate in pup neurons. A–C, An example used to illustrate the method used to predict the 50% cutoff rate. From the delay–frequency tuning curve of each neuron (A), the spectral distance between the HIF and the HEF was estimated. In this example, HIF − HEF was 5 kHz. From the TTI curve (B), the arrival time of inhibition that caused 50% suppression from control response was estimated. In this example, 50% arrival time was 1 ms. The predicted 50% cutoff rate for this neuron was 5 kHz/1 ms = 5 kHz/ms. The measured rate selectivity functions (C) show that the 50% cutoff for this neuron was 5.5 kHz/ms, supporting the prediction. The horizontal dashed line is the 50% response, and the vertical dashed line shows the time at which response decreased to 50% of control. D, A summary plot based on data from 49 pup cortical neurons shows a good correlation (r² = 0.7; p < 0.001) between the predicted and actual 50% cutoff rates.