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. 2007 Feb 14;27(7):1682–1691. doi: 10.1523/JNEUROSCI.3439-06.2007

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Copyright © 2007 Society for Neuroscience 0270-6474/07/271682-10$15.00/0

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Figure 6. — Effect of SAP97 siRNA on ADAM10 localization and APP metabolism. A, siRNA knockdown of SAP97 decreases ADAM10 in postsynaptic compartment. Representative immunoblot for SAP97, SAP102, ADAM10, and CaMKII in total homogenate (Homo) and TIF of hippocampal neurons infected with control (empty) lentivirus or lentivirus expressing siRNA against SAP97 (SAP97i). B, siRNA knockdown of SAP97 decreases CTF83/CTF99 ratio in hippocampal neurons infected with lentivirus expressing SAP97i compared with neurons infected with control (empty) lentivirus. TIF proteins were separated by 15% Tris-tricine gel, and APP CTFs were revealed by immunoblotting with 4G8 antibody.