Table 4.

Changes in firing rates, oscillatory firing patterns, and synchronization in pallidal neurons continuously recorded over the Off–On transition

	Optimal treatment state					Dyskinetic treatment state
A. Firing rate
	n	Net changea	Incb	NCb	Decb	n	Net changea	Incb	NCb	Decb
GPe	12	↑ *1.6 (+36 spk/s)	9 (75%)	3 (25%)	0 (0%)	44	↑ *2.2 (+38 spk/s)	37 (84%)	3 (9%)	4 (7%)
GPi	4	↓ *1.2 (−10 spk/s)	1 (25%)	1 (25%)	2 (50%)	4	↓ *1.8 (−27 spk/s)	0 (0%)	0 (0%)	4 (100%)
B. Oscillatory firing patternc
	n	Osc↓NoOsc	Osc↓Osc	NoOsc↓NoOsc	NoOsc↓Osc	n	Osc↓NoOsc	Osc↓Osc	NoOsc↓NoOsc	NoOsc↓Osc
GPe	12	17%	8%	75%	0%	44	12%	2%	84%	2%
GPi	4	0%	75%	25%	0%	4	0%	50%	50%	0%
C. Pairwise neuronal synchronizationd
	n	Cor↓NoCor	Cor↓Cor	NoCor↓NoCor	NoCor↓Cor	n	Cor↓NoCor	Cor↓Cor	NoCor↓NoCor	NoCor↓Cor
GPe	13	15%	15%	70%	0%	101	46%	26%	25%	3%
GPi	5	40%	40%	20%	0%	2	100%	0%	0%	0%

GPe continuously recorded cells are from both monkeys.

^aThe average change of firing rate for all continuously recorded cells. The change is expressed as the factor by which the average rate increased or decreased and by spikes per second (spk/s).

^bThe number of cells that decreased (Dec), increased (Inc), or did not change (NC) their discharge rate significantly after the medication. An increase or decrease of >10% from the baseline rate of the cell was considered significant.

^cThe fraction of cells that changed their discharge pattern from oscillatory (Osc) to non-oscillatory (NoOsc), remained oscillatory, remained non-oscillatory, or changed their pattern from non-oscillatory to oscillatory in response to the medication.

^dThe fraction of neuronal pairs that changed their correlation mode from correlated (Cor) to noncorrelated (NoCor), remained correlated, remained noncorrelated, or changed their mode from noncorrelated to correlated in response to the medication.