Figure 8.

Effect of MeA infusion (once at day 1) of BDNF sense and antisense ODNs and/or BDNF (twice; first infusion at day 1 and second infusion at day 2) on alcohol preference as measured by the two-bottle free-choice paradigm. Results represent the percentage of 7% v/v (ethanol in water solution) ethanol intake and percentage of water intake of total fluid intake (milliliters per day). Values are the mean ± SEM of six rats in each group, and alcohol intake was measured for 4 d in the same group of rats. Asterisks indicate significant (p < 0.001) difference from aCSF-infused rats.