Figure 3.

Voltage dependence of Up and Down state durations. a, Membrane potential during ±400 pA constant current injection and at rest (no current injection). The dashed line denotes −80 mV. b, Cumulative membrane potential histograms corresponding to data shown in a. Changes in the position of the inflection point (dashed lines) during current injection are indicated by arrows. c, Effect of constant current injection on the proportion of time spent in Up and Down states. Data points represent means (±SEM). Pooled data from five neurons are shown. The linear fit had a slope of 1.7 ± 0.9% per millivolt.