Figure 8.

Depolarization per active synapse in the full morphology model. A, Steady-state depolarization with asynchronous (Poisson-distributed), spatially distributed inputs as a function of number of active excitatory synapses per millisecond in the presence and absence of anomalous rectification (AR). The lines and gray shaded areas represent mean and minimum/maximum values, respectively. The dashed horizontal line is AP threshold of −36.4 mV (Table 1). An exponential fit to the relationship with anomalous rectification (data not shown) crossed AP threshold at 14.2 synapses per millisecond. B, Peak EPSP amplitudes of synchronous excitatory inputs to the basal dendrites from Up or Down states as a function of the number of inputs.