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TUNEL analysis in sagittal sections of the VNO at E13 showing increased cell death in CXCR4−/− VNO neurons as compared with wild-type controls. A, In control animals at this age the basal level of apoptosis is low; no TUNEL-positive cells are detectable in this control image. B, In CXCR4−/− VNO there is a significant increase in TUNEL-positive cells, most of which are found in the ventral half of the VNO. Scale bar, 25 μm.
