Magnitude and extent of accumbens and OFC activity to reward. A, Adolescents showed exaggerated percent change in MR signal to large reward relative to children and adults in the accumbens. B, In the OFC, children had the greatest percent change in MR signal relative to adolescents and adults. C, Children showed the largest volume of activity in the accumbens relative to adolescents and adults. D, Children and adolescents showed greater volume of activity in the OFC relative to adults. Error bars indicate SEM. Asterisks denote significant activation differences between children and adolescents and adolescents and adults in A; greater activation in children relative to adolescents and adults in B; greater volume of activity in children relative to adolescents and adults in C; and greater volume of activity in children relative to adolescents and adolescents relative to adults in D.