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. 2006 Jun 21;26(25):6677–6686. doi: 10.1523/JNEUROSCI.0153-06.2006

Figure 5.

Figure 5.

CB1 deficiency impairs long-term habituation to a loud tone. A, Naive CB1−/− (n = 13) and CB1+/+ (n = 15) were exposed to a loud tone of 95 dB at days 1 and 6. B, CB1−/− and CB1+/+ showed a similar short-term habituation to the first tone presentation but differed in their freezing response to the second tone presentation (mean ± SEM). C, CB1+/+, but not CB1−/−, showed a decrease in the freezing responses to the tones from day 1 to day 6 (mean). Data were normalized either to 20 s observation intervals (B) or to the entire 180 s observation period (C). ∗p < 0.05. •, CB1−/−; ○, CB1+/+; d1, day 1; d6, day 6.