Skip to main content
. 2006 Jun 21;26(25):6687–6694. doi: 10.1523/JNEUROSCI.1618-06.2006

Figure 8.

Figure 8.

Simplified model of the role of Kiss1 neurons in the generation of the GnRH/LH surge. According to this model, Kiss1 neurons in the AVPV receive circadian signals from the SCN and sense circulating E levels via estrogen receptors (ER), which are expressed within these neurons. When E levels and the circadian signal are both high, Kiss1 neurons become activated, causing kisspeptin to be released at synapses on GnRH neurons. Kisspeptin activates those GnRH neurons, driving the release of GnRH into the portal circulation. mPOA, Medial preoptic area.