Table 1.
Basal neural transmission in tau-P301L transgenic and nontransgenic mice
| WT CA1 (n = 12) | P301L CA1 (n = 7) | WT DG (n = 7) | P301L DG (n = 5) | |
|---|---|---|---|---|
| Slope | ||||
| Rmax (mV/ms) | −2.3 ± 0.6 | −2.2 ± 0.4 | −1.7 ± 0.7 | −1.8 ± 0.7 |
| Ih (arbitrary units) | 196 ± 4 | 200 ± 6 | 197 ± 9 | 206 ± 8 |
| Slope factor | −6.0 ± 0.7 | −9.8 ± 1.8 | −4.1 ± 1.7 | −7.0 ± 3.2 |
| Amplitude | ||||
| Rmax (mV) | −3.0 ± 0.1 | −2.4 ± 0.2 | −1.8 ± 0.4 | −2.2 ± 0.3 |
| Ih (arbitrary units) | 196 ± 3 | 188 ± 4 | 193 ± 10 | 199 ± 6 |
| Slope factor | −8.8 ± 0.7 | −7.1 ± 1.3 | −4.3 ± 2.9 | −6.2 ± 1.3 |
Basal neural transmission is unchanged in tau-P301L transgenic mice, whether recorded in the CA1 or DG. Values are mean ± SEM. Rmax, Maximal response; Ih, half-maximal stimulation intensity.