Figure 1.
Age course of alterations in Ca2+-dependent AHPs in CA1 neurons during aging. A, Representative examples of AHPs recorded in CA1 neurons from a young-adult (4 months) and an aged (23 months) animal illustrating where measurements were taken (arrows). B–D, Quantitative group changes in sAHP amplitude and duration and mAHP amplitude, respectively. E, Representative examples of spike frequency accommodation in a 4-month-old (top) and a 23-month-old (bottom) animal. F, Group results on measures of spike-frequency accommodation (number of action potentials generated during an 800 ms depolarization). *Significantly different from the 4-month-old group at p < 0.05. Means ± SEM are shown. Note that the earliest detectable changes occurred for all variables at 12 months of age.