Figure 7.

Improved maintenance of synaptic strength during sustained stimulation at higher temperatures. Synaptic responses to trains of different duration (green traces, 25 stimuli; red traces, 50 stimuli; blue traces, 150 stimuli; cyan traces, 300 stimuli) at 10 Hz (A, B) and 40 Hz (C, D) were recorded to evaluate the ability to maintain synaptic strength during prolonged synaptic use at near body temperatures (n = 5). Representative fEPSP responses to 300-stimulus trains at 10 Hz (A) or 40 Hz (C) at 33°C are shown on the top, and the average normalized fEPSP slopes for 10 Hz (B) and 40 Hz (D) trains are plotted below. The raw traces were processed for presentation only as described in Materials and Methods.