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. 2006 Jun 28;26(26):6985–6996. doi: 10.1523/JNEUROSCI.0746-06.2006

Figure 4.

Figure 4.

Presynaptic and perikaryal accumulation of phospho-tau but not Alzheimer-type tau conformational epitopes in CHIP−/− mice. A, Neocortical sections show diffuse neuropil immunoreactivity with CP13 (pS202/T205) revealing a negative outline of apical dendrites of pyramidal neurons. B–D, CP13 immunoreactivity was present in occasional neuronal perikarya in the olfactory bulb (B), midbrain tectum (C), and cerebellar deep nuclei (D), regions that also had increased neuronal apoptosis (see Fig. 7D,E). E, G, I, K, M, Adjacent sections of the hippocampal CA3 sector of a CHIP−/− mouse show phospho-tau immunoreactivity of mossy fibers with CP13 (pS202/T205; E), PHF1 (pS396/S404; G), 12E8 (pS262/S356; I), and tau 5 (total normal tau; K) but not MC1 (Alzheimer-type conformational tau epitope; M). F, H, In the cerebellar molecular layer, there is diffuse neuropil staining of the molecular layer, consistent with a presynaptic distribution with antibodies to phospho-tau, CP13 (F), and PHF1 (H). J, L, N, There is more perikaryal staining with 12E8 (J) and tau 5 (L) but neither neuropil nor perikaryal immunoreactivity with MC1 (N).