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. 2006 Jul 5;26(27):7272–7280. doi: 10.1523/JNEUROSCI.0837-06.2006

Figure 9.

Figure 9.

7-OH-DPAT promotes functional recovery after denervation in a rodent model of PD. Functional asymmetry was assessed before and after 7-OH-DPAT treatment using two standard behavioral measures. A, Counts of amphetamine-induced rotations 3 d after 0, 2, 4, or 8 weeks of treatment. Each point represents the mean (±SEM, n = 6) number of ipsilateral rotations expressed as a percentage of pretreatment values. Significant difference from saline-treated controls, ∗∗p < 0.001. B, Counts of amphetamine-induced rotations at various time points after the termination of 8 weeks of treatment. Each bar represents the mean (±SEM, n = 3–6) number of ipsilateral rotations expressed as a percentage of pretreatment values. Significant difference from saline-treated controls, ∗∗p < 0.001. C, Counts of pellets eaten in the staircase test. D, Counts of the number of steps reached in the staircase test. Each point represents the mean (±SEM, n = 6) number of pellets eaten or steps reached. Significant difference from ipsilateral paw, ∗∗p < 0.001. Squares, Ipsilateral paw; triangles, contralateral paw; open symbol, saline treatment; filled symbol, 7-OH-DPAT treatment.