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Prolonged repetitive and high-frequency stimulation of WT and APP KO neurons. A, Sample recordings of the first 10 responses in a 10 Hz train. B, Average EPSC amplitudes of wild-type (n = 19) or APP knock-out (n = 16) neurons during 10 Hz train normalized to the size of first response. C, Sample recordings of five responses in a 50 Hz train. D, Average EPSC amplitudes of wild-type (n = 22) and APP knock-out (n = 23) cells during 50 Hz train normalized to the size of first response.
