Figure 7.

Axodendritic distribution of total CaMKII immunoreactivity at primary afferent synapses after capsaicin stimulation. The axodendritic distributions of CaMKII immunogold labeling relative to the postsynaptic membrane (presynaptic gold particle distances negated), normalized by the number of synapses are shown for SP⁺/CGRP⁺ (A), peroxidase⁺ (B), and LTM (C) synapses. The dashed lines indicate the position of the extracellular face of the postsynaptic membrane. Error bars indicate SEM. ∗p < 0.05, ∗∗p < 0.01, repeated-measures two-way ANOVA followed by Bonferroni’s post hoc test. P_caps, Statistical significance of capsaicin effect; P_dist, statistical significance of distance effect; P_i, statistical significance of interaction between capsaicin and distance effects.