Figure 4.

Thirty days after SCI, dorsal horn multireceptive units were sampled from the lumbar enlargement of SCI animals after acute topical administration of minocycline (arrow). The time course for maximum depression of evoked response to press stimulation of a receptive field located on the hindpaw after administration of minocycline revealed peak efficacy at 25–45 min for 100 μg. For subsequent electrophysiological experiments, units were sampled at time points of peak efficacy (shaded region).