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. 2006 Apr 19;26(16):4216–4227. doi: 10.1523/JNEUROSCI.0589-06.2006

Figure 8.

Figure 8.

GAT-2/3 operates in the reversed mode supporting GABABR-mediated presynaptic inhibition. A, Sample traces showing mIPSCs recorded in the control (top recordings) and in the presence of SNAP-5114 (40 μm; bottom recordings). B, SNAP-5114 increased mean mIPSC frequency but did not affect mIPSC amplitude and kinetics. Statistical data were obtained from seven CR cells. C, SNAP-5114 increased eIPSC amplitude but did not affect eIPSC kinetics (n = 11). D, Averaged paired-pulse eIPSCs (40 trials) recorded in the control, in the presence of SNAP-5114, and in the presence of SNAP-5114 plus CGP55845. Traces were recorded from the same cell. E, SNAP-5114 decreased the PPR. Statistical data were obtained from six CR cells. F, Paired-pulse eIPSCs recorded in the presence of CGP55845 or CGP55845 plus SNAP-5114. Traces represent an average of 40 sequential responses. Data were obtained from the same cell. G, Statistical data showing SNAP-5114 effects on PPRs in the presence of CGP55845 (left; n = 5) or 3-MP (right; n = 5). Error bars indicate SEM. ∗p < 0.05; ∗∗p < 0.01. Ampl., Amplitude; Freq., frequency; CGP, CGP55845; Cont., control.