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. 2006 Jun 14;26(24):6450–6457. doi: 10.1523/JNEUROSCI.0491-06.2006

Figure 2.

Figure 2.

Effects of naloxone dose on CREB and GluR1 phosphorylation. Morphine-dependent and control rats were treated with naloxone (0.0–1.0 mg/kg, s.c.) 3 d after pellet implants and killed 30 min later. Tissue from the NAc or CPu was subjected to Western blot analysis for P-CREB (A, B) or P-GluR1 (C, D) followed by actin as a control. Data are presented as the fold induction of P-CREB/actin or P-GluR1/actin in morphine-dependent rats compared with placebo-implanted control rats for each dose of naloxone (means ± SEM). *p < 0.05; **p < 0.01 compared with naloxone (0.0), Fisher’s protected t tests, five to nine rats per group. Insets, Nonimplanted rats were treated with vehicle (H2O) or LiCl (120 mg/kg, s.c.) and killed 30 min later. Tissue from the NAc or CPu was assessed by Western blot for P-CREB or P-GluR1 followed by actin as a control. Data are expressed as the fold induction of P-CREB/actin or P-GluR1/actin from LiCl-treated rats compared with vehicle-treated rats (means ± SEM). **p < 0.01 compared with vehicle, Student’s t tests, eight rats per group. P, Placebo; M, morphine; V, Veh, vehicle; L, LiCl.