Figure 4.

5-HT clearance-inhibiting effects of either locally or systemically administered ethanol are potentiated by cotreatment with a 5-HTT antagonist in 5-HTT+/+ mice. A, Local coadministration of ethanol and fluvoxamine produced a significantly greater increase in T₈₀ values in the hippocampus than either treatment alone (n = 4–5/treatment). B, Systemic coadministration of ethanol and fluvoxamine produced a significantly greater increase in T₈₀ values in the hippocampus than either treatment alone (n = 5–6/treatment). ^★p < 0.05.