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. 2006 Apr 26;26(17):4649–4659. doi: 10.1523/JNEUROSCI.5409-05.2006

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Copyright © 2006 Society for Neuroscience 0270-6474/06/264649-11$15.00/0

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Figure 2. — The overexpression of CA150 or CA150ΔQA does not produce a striatal pathology in rats. Striatal toxicity was assessed using DARPP-32 and Neu-N immunostaining. Immunostaining for extragenous CA150 is shown (HA epitope). No lesion was observed at 8 or 12 weeks compared with animals injected with htt171-19Q lentiviruses. A, Simple infections analyzed at 8 weeks. B, Double infections analyzed at 12 weeks. C, Striatal sections incubated only with the secondary antibodies (left panel, no primary DARPP-32 antiserum; right panel, no Neu-N antibody) show no immunostaining.