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. 2006 Apr 26;26(17):4649–4659. doi: 10.1523/JNEUROSCI.5409-05.2006

Figure 6.

Figure 6.

Effect of overexpression of CA150 species in 109Q/109Q striatal lines. A, CA150 overexpression reduces cell death induced in 109Q/109Q striatal lines compared with cells transfected with empty vector (∗∗∗p < 0.0001). No difference in cell death was observed in cells overexpressing CA150ΔQA compared with cells transfected with the empty vector. Overexpression of a CA150 fragment containing the QA repeat and 16 aa N-terminal and 76 aa C-terminal to the repeat (CA150162–331) was toxic for 7Q/7Q cells compared with cells transfected with empty vector (p < 0.0001). Data are mean ± SD of six independent experiments (100–150 cells counted per experiment). B, No noticeable difference of htt expression by CA150 species or (QA)38 overexpression was observed as tested by Western blotting.