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. 2006 Mar 22;26(12):3220–3228. doi: 10.1523/JNEUROSCI.3780-05.2006

Figure 2.

Figure 2.

Complement increases plasma membrane conductance and [Ca2+]i in glutamate-sensitized oligodendrocytes. A, Effect of complement (LTC) on oligodendroglial membrane conductance after pretreatment with glutamate (Glu; 5 mm for 10 min; n = 15). Current induced by LTC after glutamate pretreatment was blocked in the presence of CNQX (30 μm; n = 6) but not in the presence of GYKI53655 (100 μm; n = 8). Note that the membrane conductance of oligodendrocytes exposed exclusively to LTC (vehicle; n = 7) or to HI-LTC (n = 6) was not altered. B, Increase in [Ca2+]i in oligodendrocytes exposed to glutamate (Glu; 10 μm) and then to LTC is blocked by CNQX (30 μm) and by removal of Ca2+ from the medium but not by GYKI53655 (100 μm) or by Thp (0.5 μm). The curves illustrate average ± SEM responses of 15–52 cells from at least five different experiments. C, Percentage of oligodendrocytes showing massive Ca2+ influx during LTC incubation subsequent to exposure to different concentrations of glutamate or AMPA. Values represent average ± SEM of at least five experiments (n = 750 cells).