Table 1.
Concentrations (μm/L) of the principal species in the spine at rest, immediately, and 60 min after 1, 5, 10 Hz stimulation in WT
Species | t = 0 | 1 Hz |
5 Hz |
10 Hz |
|||
---|---|---|---|---|---|---|---|
t = 900a | t = 3600 | t = 180a | t = 3600 | t = 90a | t = 3600 | ||
Ca2+ | 0.10 | 0.80 | 0.10 | 1.0 | 0.10 | 0.10 | 0.10 |
CaM | 0.90 | 0.90 | 0.90 | 0.89 | 0.90 | 0.92 | 0.90 |
CaCaM | 9.0 × 10−7 | 2.5 × 10−4 | 9.0 × 10−7 | 6.0 × 10−4 | 9.0 × 10−7 | 9.9 × 10−7 | 9.0 × 10−7 |
Ng | 0.77 | 0.77 | 0.77 | 0.77 | 0.77 | 0.77 | 0.77 |
CaM·Ng | 0.23 | 0.23 | 0.23 | 0.23 | 0.23 | 0.23 | 0.23 |
CaCaM·Ng | 2.3 × 10−7 | 6.4 × 10−7 | 2.3 × 10−7 | 2.8 × 10−5 | 2.3 × 10−7 | 2.5 × 10−7 | 2.3 × 10−7 |
CaN* | 4.5 × 10−4 | 9.6 × 10−3 | 4.5 × 10−4 | 0.13 | 4.5 × 10− | 5.0 × 10−4 | 4.5 × 10−4 |
PP1act | 9.0 × 10−5 | 2.7 × 10−3 | 9.0 × 10−5 | 2.8 × 10−2 | 9.0 × 10−5 | 1.0 × 10−4 | 9.0 × 10−5 |
CaMKIIact | 1.8 × 10−4 | 4.9 × 10−3 | 1.8 × 10−4 | 0.41 | 1.8 × 10−4 | 3.3 × 10−3 | 1.8 × 10−4 |
R | 0.30 | 3.5 × 10−2 | 0.19 | 4.8 × 10−4 | 0.17 | 6.4 × 10−3 | 0.18 |
Rp | 6.9 × 10−2 | 3.7 × 10−2 | 4.2 × 10−2 | 2.2 × 10−2 | 3.8 × 10−2 | 4.6 × 10−3 | 4.1 × 10−2 |
Rps | 0.34 | 0.16 | 0.21 | 3.3 × 10−2 | 0.19 | 2.3 × 10−2 | 0.20 |
SAP97p·Rps | 1.9 × 10−2 | 0.12 | 5.8 × 10−2 | 0.25 | 0.10 | 0.49 | 0.18 |
Rd | 0.18 | 0.73 | 0.69 | 0.88 | 0.80 | 0.78 | 0.71 |
Rf | 2.0 × 10−4 | 5.3 × 10−4 | 1.2 × 10−4 | 1.4 × 10−4 | 5.7 × 10−5 | 7.1 × 10−6 | 4.4 × 10−5 |
SAP97 | 0.70 | 0.61 | 0.69 | 0.44 | 0.69 | 0.32 | 0.68 |
SAP97p | 5.6 × 10−6 | 1.3 × 10−4 | 5.7 × 10−6 | 8.1 × 10−3 | 5.8 × 10−6 | 4.8 × 10−5 | 6.0 × 10−6 |
aEnd of stimulation.