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. 2006 May 10;26(19):5049–5058. doi: 10.1523/JNEUROSCI.4381-05.2006

Figure 1.

Figure 1.

Acute inactivation of the mPFC completely abolishes retrieval of remotely acquired memory. A, Mean percentage of adaptive CRs during the last 3 d of the initial conditioning and reconditioning. Negative values on the abscissa represent the last 3 d of the initial conditioning (the session in which the rat reached the criterion is denoted −1), and positive values represent the reconditioning. During reconditioning, the muscimol group (muscimol, n = 6; filled circles) exhibited significantly fewer adaptive CRs in sessions 1 and 3 when it received the muscimol infusion than did the PBS group (PBS, n = 6; open circles), although the same group could exhibit comparable adaptive CRs in session 2 when it received PBS infusion. B, Averaged EMG amplitude of the PBS group (thin line) and the muscimol group (thick line) in session 1. The solid line under each trace indicates the timing of the 350 ms CS and the 100 ms US. The vertical scale indicates the average EMG amplitude before the CS presentation. The EMG amplitude of the muscimol group showed little increase after the CS onset.