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The NMDA receptor antagonist d-APV blocks LTP in the hippocampal-prefrontal cortex pathway. A, Typical field potentials immediately before (pre) and after (post) HFBS application. Calibration: 0.1 mV, 5 ms. B, Time course of changes in fEPSP slopes in anesthetized rats treated with aCSF (empty circles) and rats treated with d-APV (filled circles). HFBS was applied to the CA1/ventral subicular area at time 0 min. All data points represent group mean ± SEM of 6–10 animals.
