Figure 3.

Locomotor activity in the open field test. A, B, Locomotor activity in wild-type (A) and Adcyap1^−/− (B) mice that received 2 mg/kg amphetamine (closed circles) or saline (open circles). n = 16 per group. ∗p < 0.05 and ∗∗p < 0.01 versus saline. C, Representative locomotor patterns of saline-treated (top panels) or 2 mg/kg amphetamine-treated (bottom panels) wild-type (left panels) and Adcyap1^−/− (right panels) mice during 25–30 min of a 90 min recording in an open field test. Data are expressed as means ± SEM.