Figure 5.

Locomotor activity in the open field test. A–D, Locomotor activity in wild-type (A, C) and Adcyap1^−/− (B, D) mice that received 0.05 mg/kg 8-OH-DPAT (triangles), 0.3 mg/kg WAY-100635 (squares), or saline (circles) either alone (open symbols) or in combination with 2 mg/kg amphetamine (closed symbols). The results of the experiment with amphetamine or saline alone are the same as those in Figure 3. n = 15–16 per group. ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001 versus saline alone; ^†p < 0.05, ^††p < 0.01, and ^†††p < 0.001 versus amphetamine. Data are expressed as means ± SEM.