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Schematic time line illustrating changes in AD-linked pathology during aging of NonTg, PS1KI, and 3xTg-AD mice. Data on cognitive abilities are from studies by Verbitsky et al. (2004), Billings et al. (2005), and Janus et al. (2000), and data on appearance of plaques and tangles are from the studies by Oddo et al. (2003a,b).
