Figure 7.

TNFR1 mediates the TNFα-induced modulation of TTX-R Na⁺ currents. A, Representative time courses of the peak TTX-R current showing the effect of bath application of TNFα in DRG neurons prepared from WT, TNFR1^–/–, or TNFR2^–/– mice. B, Mean ± SEM percentage change of TTX-R peak currents induced by TNFα in TNFR1^–/– and TNFR2^–/– DRG cells compared with wild type. C, Mean ± SEM percentage change of TTX-R peak currents induced by the p38 inhibitor SB202190 (10 μm) in TNFR1^–/– and TNFR2^–/– DRG cells compared with wild type.