Figure 8.

p38 activity is required for mechanical hypersensitivity induced by TNFα. ICR mice were pretreated with the p38 inhibitor SB202190 (12 μm in 10 μl) or vehicle (0.1% DMSO) alone or 20 min before intraplantar injection of TNFα (1 ng in 10 μl). The graph shows the mean ± SEM mechanical withdrawal thresholds over time before and after injection of TNFα. The experimenter was blind to the identity of the preinjection drug. *p < 0.05 compared with DMSO plus TNFα-treated mice. n = 6 for each condition. **p < 0.001, ANOVA compared with DMSO-treated mice.