Table 1.
Effects of TNFα (100 ng/ml) and SB202190 (10 μ m) on properties of TTX-R Na+ currents in mouse DRG neurons
|
|
V1/2 |
Slope factor |
Gmax |
||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Pre-TNFα |
Post-TNFα |
Pre-SB |
Post-SB |
Pre-TNFα |
Post-TNFα |
Pre-SB |
Post-SB |
Pre-TNFα |
Post-TNFα |
Pre-SB |
Post-SB |
|||||||||
| Activation | -24.19 ± 3.61 | -22.94 ± 6.2 | -18.86 ± 2.8 | -17.64 ± 3.3 | 4.01 ± 1.01 | 5.42 ± 1.03 | 6.76 ± 0.47 | 5.42 ± 0.52 | 121.59 ± 12.99 | 172.21 ± 25.3* | 118.92 ± 11.77 | 88.11 ± 11.34* | |||||||||
| Inactivation |
-34.13 ± 4.17 |
-43.88 ± 6.24 |
-40.64 ± 6.24 |
-39.41 ± 2.15 |
11.52 ± 1.67 |
10.65 ± 0.99 |
7.36 ± 0.76 |
8.04 ± 3.59 |
|
|
|
|
|||||||||
*
p < 0.05 indicates significant differences by paired t test. SB, SB202190.