Figure 1.

Late phase of LTP in basilar and apical dendritic compartments. A, L-LTP induced by four trains of 100 Hz (4 HFS) evoked at basal dendrites(filled squares; n=6) is disrupted by actinomycin-D(40μm)(ACT-D, open triangles; n=6) and anisomycin(20μm)(gray squares; n = 6). B, L-LTP induced by four trains of 100 Hz evoked at apical dendrites (filled circles; n = 6) is disrupted by actinomycin-D (ACT-D, open triangles; n = 6) and anisomycin (gray circles; n = 6). Horizontal bars represent the time the drug was applied onto slices. S1 and S2 represent pathways synapsing on basal and apical dendrites of the CA1 area, respectively. Data are represented as mean±SEM.