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. 2006 Jan 4;26(1):256–264. doi: 10.1523/JNEUROSCI.3196-05.2006

Figure 3.

Figure 3.

Synaptic tagging is similar in the apical and basilar dendritic compartments. A, Antidromic stimulation facilitates the formation of L-LTP in basal dendrites. After antidromic stimulation (4 HFS; dots at 0 h), one train of 100 Hz (1 HFS) delivered to basal dendrites induced L-LTP (filled squares; n = 6). This form of L-LTP was disrupted by KT5720 (1 μm, dashed horizontal bar, open squares; n=6)and was reduced by anisomycin (20μm, gray horizontalbar, gray squares; n=6).B, Antidromic stimulation also facilitated the formation of L-LTP in apical dendrites that was sensitive to KT5720 (1μm, dashed horizontal bar, open circles; n=6)and anisomycin(20μm, gray horizontalbar, gray circles; n=6). In A and B, kynurenic acid (3 mm, black horizontalbar) was used to avoid synaptic activation from axon collaterals during antidromic stimulation. C, Facilitated L-LTP in basal dendrites by VP16-CREB expression (filled squares; n = 6). D, Facilitated L-LTP in apical dendrites by VP16-CREB expression (filled squares; n = 6). Data are represented as mean ± SEM.