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. 2006 Aug 23;26(34):8847–8856. doi: 10.1523/JNEUROSCI.1919-06.2006

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Copyright © 2006 Society for Neuroscience 0270-6474/06/268847-10$15.00/0

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Figure 6. — Translocation of calcium-dependent Apl I requires sensory neuron firing concurrent with 5-HT application. A, Cell body (top) and neurite (bottom) of a sensory neuron expressing eGFP-Apl I in control condition (Pre), with stimulation of the sensory neuron at 10 Hz (Stim), subsequent application of 5-HT, stimulation in the presence of 5-HT (5-HT+Stim), and after cessation of stimulation, still in the presence of 5-HT (Recovery). Translocation of fluorescence is clear only with conjoint 5-HT and firing and recovers when the stimulation is stopped. B, Ratio of membrane fluorescence to cytoplasmic fluorescence (calculated as in Fig. 5A) in three to nine experiments on sensory neurons and two to five experiments on motor neurons. Translocation in the sensory neurons is significantly greater than that in the motor neurons (p < 0.01; two-way ANOVA).