Figure 8.

Effects of PP2 on nerve injury-induced neuropathic pain behaviors and ERK activation in the dorsal horn. A, Mechanical hypersensitivity was determined with a Dynamic Plantar Aesthesiometer at days 3, 5, and 7 after L5 SNL. Data represent mean ± SD; n = 8 per group. B, Western blot analysis indicates that PP2 suppresses the activation of ERK in the ipsilateral spinal cord at day 7 in a dose-dependent manner. Quantification of Western blot data are shown at right. Data represent mean ± SD; n = 4 per group. *p < 0.05 compared with the naive control. ^#p < 0.05, ^##p < 0.01 compared with vehicle control.