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. 2006 Jan 11;26(2):597–608. doi: 10.1523/JNEUROSCI.4493-05.2006

Figure 4.

Figure 4.

Mossy fibers releasing glutamate into target neurons can be recruited by increasing the strength of stimulation. A, Top traces, Average of 20 individual traces (successes plus failures) evoked in a principal cell (at 33°C and at -70mV; arrow) by minimal stimulation of the granule cell in the dentate gyrus in control and in the presence of l-AP-4 and l-AP-4 plus picrotoxin (PTX). The inset above the traces shows average pair responses obtained in control. Bottom traces, Average of 20 responses evoked in another neuron in the presence of picrotoxin (100 μm) by increasing stimulus strength (from 3 to 13 V; double arrows). B, Summary data from eight principal cells showing the mean amplitude of the GABAergic (white columns) and glutamatergic (black columns) components of synaptic currents evoked in different experimental conditions. C, Average traces recorded from an interneuron (same legend as in A). D, Summary data from eight interneurons showing the mean amplitude of the GABAergic (white columns) and glutamatergic (black columns) components of synaptic currents obtained in the same experimental conditions as in B.