Table 3.

Brain areas activated during the comparison of fMRI signal change differences (after treatment > before treatment) between both placebo and control sides

fMRI signal change difference	Area (Brodmann area)	Z score	Number of voxels in cluster	Peak coordinate (x, y, z)
Within mask
P > C	Right anterior insula	3.21	30	46, 20, -4
C > P	Left M1 (4)	4.00	170	-18, -18, 60
Outside mask
P > C	Right inferior parietal lobule (40)	4.19	240	60, -36, 52
	Left superior frontal gyrus (6)	3.57	47	-20, 20, 66
	Right inferior frontal gyrus/anterior insula (47)	3.50	105	48, 22, -2
	Left inferior parietal lobule (40)	3.38	164	-56, -54, 46
	Left middle frontal gyrus (10)	3.33	74	-46, 50, 12
	Right middle frontal gyrus (10)	3.05	31	40, 58, 2
	Right middle frontal gyrus (46, 9)	3.02	36	52, 38, 26
	Left inferior frontal gyrus (44)	2.98	87	-54, 12, 28
	Bilateral rACC (32)	2.96	33	2, 44, 10
	Right inferior frontal gyrus (46)	2.86	27	48, 40, 8
	Right supramarginal gyrus (40)	2.81	29	60, -58, 32
C > P	Nothing above threshold

The threshold is set to voxel-wise p < 0.005 with 20 continuous voxels for predefined ROIs and voxel-wise p < 0.001 uncorrected with 20 contiguous voxels and cluster p < 0.05 corrected for other regions. Peak coordinates refer to the MNI atlas. P, Placebo; C, control.